Santhiago is a spelling variant of Santiago, the Spanish name for "Saint James", formed from Santo and Iago, the old Spanish form of James, which in Hebrew means "supplanter". The h echoes Thiago, the Portuguese short form. In the United States Santhiago rose from number 3859 in 2015 to number 2104 among boys' names in 2025, its highest rank so far, while Santiago itself sits in the top 100.