Santiago is the Spanish name of Saint James, from Sant Iago, and means "Saint James"; the apostle's shrine at Santiago de Compostela is the goal of the famous pilgrim road. It is the most Spanish of boys' names and a favorite across Latin America, which shows in the US numbers. Santiago stood at number 359 in 2000, entered the top 100 in 2017 and ranks twenty-sixth in 2025, its highest ever.