Itzayana is a modern name popular in Mexico and among Mexican American families; its origin is uncertain, and it is usually explained as a Maya-inspired creation meaning "gift of God", although that reading is not documented. Its sound places it alongside Itzel and Ximena. Itzayana entered the US top 1000 in 2016, peaked at number 760 in 2018 and has slipped since; in 2025 it ranks number 1637 with 127 girls.