Isaac comes from the Hebrew Yitzchaq and means "he will laugh" or "laughter", because his elderly mother Sarah laughed when she was told she would have a son. The biblical patriarch is the son of Abraham and father of Jacob, and scientist Isaac Newton gave the name intellectual weight. Isaac ranked number 53 in the United States in 2000, peaked at number 28 in 2013 and has held a place in the 30s and 40s since, standing at number 47 among boys in 2025.