Zissy is a Yiddish name built on the word zis, "sweet", and is a pet form of Zissel, a traditional name in Ashkenazi Jewish families. In the United States it is given almost exclusively in Orthodox communities, where names like Chaya, Rivky and Malky are also common. Zissy ranked number 5935 in 2000, has generally sat between number 2900 and 3800 over the past decade and reaches its best rank, number 2437, in 2025 with 74 girls.