Wynona is a spelling of Winona, a Dakota Sioux name that means "firstborn daughter". The spelling with y is associated with country singer Wynonna Judd, while the city of Winona, Minnesota and actress Winona Ryder keep the original form in view. Wynona has climbed from number 9459 among US girls in 2015 to number 2605 in 2024 and ranks 2820 in 2025.