Brysen is a modern American respelling of Bryson, an English surname that means "son of Brice"; Brice itself goes back to a Celtic name usually explained as "speckled" or "freckled". The -sen ending gives the name a slightly Scandinavian look that fits the current fashion for names like Jaxsen and Greysen. Brysen entered the US top 1000 in 2011, peaked at number 844 in 2017 and has faded since, ranking number 2233 among boys in 2025.