Zaine is a spelling of Zane and Zain, two names that look alike but have different roots: Zane is an English surname of uncertain origin, possibly a form of John, while the Arabic Zain means "beauty" or "grace". The e ending gives the name a look like Blaine or Kaine. In the United States Zaine ranked number 2577 in 2000, peaked at number 1554 in 2015 and stood at number 2602 in 2025 with 51 boys.