Esai is the Spanish form of Jesse, in Spanish Bibles spelled Isaí, from the Hebrew Yishai, which is usually translated as "gift" or "God exists". In the Bible Jesse is the father of King David. Actor Esai Morales is the best-known American bearer. Esai peaked at number 1259 in 2002 and after a quieter stretch has climbed again, from number 2174 in 2015 to number 1591 in 2025.