Melisa is a simplified spelling of Melissa, the Greek word for "honeybee", which in myth was the name of the nymph who fed the infant Zeus with honey. The single s is the standard form in Turkish, Spanish and the Balkans. In the United States Melisa was still in the top 1000 at number 998 in 2000 and peaked at number 953 in 2004; it has since slipped to number 2950 in 2025.