Klayton is a K spelling of Clayton, an English surname and place name from the Old English claeg and tun, "clay settlement" or "farm on clay soil". The k follows a long American habit of restyling C names, from Kristopher to Kameron. Klayton stood at number 1570 in 2000, peaked at number 1403 in 2018 and ranks 1800 among boys' names in 2025.