Henderson is a Scottish surname meaning "son of Henry", from the Scots form Hendry, so it inherits Henry's meaning "home ruler". It is a common surname across the South and the name of cities in Nevada, Kentucky and North Carolina, which gives it a familiar, grounded feel as a first name. In the United States Henderson ranked number 3976 in 2000, peaked at number 2010 in 2022 and was given to 50 boys in 2025, placing it at number 2619.